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NativeExtract™ Recombinant Full Length Human NMDE1 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW149)

This product is recombinant Human NMDE1 protein in native nanodisc form. The synthetic compound we developed can solubilize the NMDE1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NMDE1
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 165.3 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • NMDE1
  • Full Name
  • Glutamate Ionotropic Receptor NMDA Type Subunit 2A
  • Introduction
  • This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • Glutamate Ionotropic Receptor NMDA Type Subunit 2A; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2A; N-Methyl D-Aspartate Receptor Subtype 2A; NMDAR2A; GluN2A; NR2A; N-Methyl-D-Aspartate Receptor Channel, Subunit Epsilon-1; Glutamate [NMDA] Receptor Subunit Epsilon-1

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