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MemDX™ Recombinant Full Length Human TGR5 Protein (Nanodisc, Rho1D4 Tag & FLAG Tag) (CAT#: SYF-0926-CW196)

Recombinant full-length human TGR5 protein reconstituted in a nanodisc membrane-mimetic system for biochemical, binding, and assay development applications.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TGR5
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 37 kDa
  • Sequence
  • TPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN

Product Description

  • Expression Systems
  • Insect cells
  • Tag
  • The construct includes an N-terminal FLAG tag and a C-terminal Rho1D4 tag.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • TGR5
  • Full Name
  • G protein-coupled bile acid receptor 1
  • Introduction
  • G-protein coupled bile acid receptor 1 (TGR5) is a full-length human gpcr. It functions as a receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. The protein is supplied in an MSP-free, copolymer-stabilized native-lipid nanodisc. The preparation uses 2-step purification.
  • Alternative Names
  • BG37, GPCR, TGR5, M-BAR, GPCR19, GPR131, MGC40597

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