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NativeExtract™ Recombinant Full Length Human TPC2 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW55)

This product is recombinant Human HCN2 protein in native nanodisc form. The synthetic compound we developed can solubilize the HCN2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TPC2
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 85.2 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • TPC2
  • Full Name
  • Two Pore Segment Channel 2
  • Introduction
  • This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.
  • Alternative Names
  • Two Pore Segment Channel 2; Voltage-Dependent Calcium Channel Protein TPC2; TPC2; Two Pore Calcium Channel Protein 2; SHEP10

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