Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsEnzyme is a substance that acts as a catalyst in living organisms, regulating the rate of chemical reactions without itself being altered in the process. Natural enzymes can catalyze reactions with up to 1017-fold rate accelerations. Currently, enzymes have been widely used as biocatalysts in pharmaceutical, industrial, and environmental fields due to their high reactivities and specificities.
Ribosome display is a fast and efficient tool for in vitro selection and evolution of antibody or protein. It has been also revealed to be applied for in vitro selection of catalytic activity. Creative Biolabs is an experienced expert in the field of in vitro display technology. We offer one-stop, all-round services to support your enzyme engineering projects based on ribosome display technology.
Recent advances in library design, and methods of random mutagenesis, combined with new screening and selection tools, provide a powerful strategy to evolve improved biocatalysts. In ribosome display technique, mRNA is not covalently attached to the protein. Thus, the mRNA can be simply eluted. Moreover, the diversity of the ribosome display library is approximately 1012~14, higher than cell-based display libraries (i.e. phage display). The random mutations can be introduced easily after each selection round, allowing the directed evolution of binding proteins over several generations. Amstutz et al. (2001) have reported the in vitro selection for catalytic activity based on catalytic turnover using ribosome display. They designed and synthesized a mechanism-based inhibitor of β-lactamase which is appropriate for the selection of catalytic activity of the ribosome-displayed β-lactamase. Under appropriate selection conditions, an active RTEM-β-lactamase was successfully enriched over an inactive mutant.
Fig.1 Principle of ribosome display selection for catalytic activity. (Amstutz, 2002)
Creative Biolabs has accumulated a lot of experience in the application of in vitro display technology. We offer a full range of services, including experiment design, carrying the experiment, data delivery and interpretation, as well as overall project management and guidance, to support your enzyme engineering projects. We can also customize and design personalized experimental programs according to your special project's purposes.
Creative Biolabs has served many clients from all over the world and won a lot of praise. We provide high-quality comprehensive solutions for the selection of enzymatic activity based on ribosome display technology. Please do not hesitate to contact us for more details.
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