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CHRNA7

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Background

Cholinergic receptor nicotinic alpha 7 (CHRNA7) is a pentameric ionotropic transmembrane receptor encoded by the CHRNA7 gene, widely expressed on neurons and microglial populations, localized to plasma membrane lipid bilayers. Distinct from other nicotinic receptor subunits, CHRNA7 forms homomeric cation channels permeable to calcium upon acetylcholine binding, modulating neuronal excitability and restraining microglial pro-inflammatory cascades. Under basal cholinergic tone, low-level receptor activation maintains balanced neural activity without excessive neuroinflammation. Upon tissue injury or cholinergic ligand stimulation, channel opening mediates calcium influx to suppress microglial cytokine secretion and preserve neural tissue homeostasis. Unlike non-selective neurotransmitter receptors, CHRNA7 bears unique anti-inflammatory cholinergic functions that cannot be fully replaced by other nicotinic subunits, linking cholinergic ligand binding directly to neuroprotective pathways. Loss of functional CHRNA7 amplifies microglial inflammatory responses and accelerates neural tissue damage, while sustained receptor activation restrains neurotoxic signaling, establishing CHRNA7 as a core research target for cholinergic membrane protein biology and neuroprotective compound screening.

CHRNA7 executes cation channel function embedded within neuronal and microglial membranes, utilizing extracellular acetylcholine binding pockets and transmembrane ion pores to mediate calcium permeation upon ligand engagement. Conserved ligand recognition domains selectively bind cholinergic agonists, separating its pharmacological spectrum from heteromeric nicotinic receptor subtypes. CHRNA7-mediated calcium influx bridges extracellular neurotransmitter sensing and intracellular anti-inflammatory transcriptional programs, balancing neuronal excitation and microglial activation intensity according to cholinergic signal abundance. CHRNA7 participates in synaptic transmission, microglial immune suppression and neuronal survival regulation. Deficient CHRNA7 channel activity disrupts cholinergic anti-inflammatory circuits. Therefore, CHRNA7 represents a pivotal research target for ionotropic receptor study and neurodegenerative compound screening.

Fig. 1 Schematic of CHRNA7 dual immune regulatory pathway under stress and non-stress conditions. (OA Literature)Fig. 1 Stress disturbs CHRNA7-mediated immune homeostasis via SLURP-1 and proinflammatory cytokines, activating ROS/HIF1α signaling to shift immunity toward innate antimicrobial response.1

CHRNA7 Protein Function: Core Roles in Cholinergic Ligand Sensing and Neuroinflammatory Tuning

The biological functions of CHRNA7 are focused on acetylcholine binding, calcium channel gating and microglial immune control:

  • Cholinergic Ligand Recognition: Captures acetylcholine and related agonists via extracellular receptor domains.
  • Calcium-Permeable Channel Gating: Opens transmembrane pores to mediate cation influx upon ligand binding.
  • Neuronal Homeostasis Maintenance: Sustains moderate synaptic signaling under resting neural conditions.
  • Neuroinflammatory Modulation: Suppresses microglial pro-inflammatory mediator release after receptor activation.
  • Disease Relevance: CHRNA7 deficiency exacerbates neuroinjury, while agonist-mediated activation confers neural tissue protection.

CHRNA7 Protein Product

Creative Biolabs offers high-quality CHRNA7 proteins through optimized expression systems, including full-length homomeric receptor subunit and isolated extracellular ligand-binding domain variants. These products are suitable for ligand-receptor interaction and neuroprotective modulator screening. All CHRNA7 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.

CHRNA7 Protein Product

Not finding the membrane protein product you need? Contact us to start your one-stop custom service!

CHRNA7 Stable Cell Line Product

Creative Biolabs provides custom-engineered CHRNA7 stable cell lines, including overexpression and blank control models. These cell lines are optimized for nicotinic receptor profiling and calcium signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.

CHRNA7 Stable Cell Line Product

Not finding the stable cell line product you need? Contact us to start your one-stop custom service!

CHRNA7 Recombinant Antibody Product

High-specificity recombinant antibodies targeting CHRNA7 are developed via advanced antibody engineering technologies. These antibodies are validated for neuronal/microglial membrane localization detection and brain tissue expression profiling, and can be combined with cholinergic marker reagents to analyze complete homomeric receptor complexes in neural cell models.

CHRNA7 Recombinant Antibody Product

Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!

Product Features

  • Native Cholinergic Binding & Channel Activity: Preserves intact ligand recognition and calcium permeation capacity for neuroinflammation research.
  • Nicotinic Subunit Specificity: Eliminates non-specific cross-recognition of other cholinergic receptor subunits.
  • Neurobiology Compatibility: Optimized reagent series for neural protection and anti-neuroinflammatory therapeutic screening workflows.
  • Comprehensive Customization Support: Facilitates end-to-end development of customized proteins, antibodies and stable cell lines to address cholinergic receptor research demands.

Custom CHRNA7 Research Services

Beyond catalog products, Creative Biolabs offers specialized custom services for CHRNA7 research:

  • Custom CHRNA7 Protein Production: Tailored expression of mutant and tagged CHRNA7 constructs for cholinergic ligand binding analysis.
  • Custom Antibody Development: Generation of CHRNA7-specific antibodies for neural membrane immunostaining in neuronal/microglial populations.
  • Stable Cell Line Engineering: Construction of CHRNA7-modified cell models for calcium and anti-inflammatory signaling research.
  • Functional Assay Development: Custom design of ligand binding and cation flux detection workflows.

Frequently Asked Questions (FAQ)

  1. What is the primary function of CHRNA7?

    CHRNA7 forms calcium-permeable homomeric nicotinic receptors that sense acetylcholine to suppress microglial neuroinflammation and regulate neuronal activity.

  2. Why is CHRNA7 a significant research target?

    CHRNA7 bridges cholinergic neurotransmission and microglial immune restraint, serving as a core neuroprotective drug target.

  3. Are Creative Biolabs' CHRNA7 products suitable for clinical use?

    No, all CHRNA7 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.

  4. What types of CHRNA7 products does Creative Biolabs offer?

    Offerings include full-length CHRNA7 receptor subunits, isoform-specific detection antibodies and custom stable cell lines for cholinergic neurobiology research.

  5. How are CHRNA7 proteins validated for activity?

    CHRNA7 proteins are validated via cholinergic ligand binding and cation permeation functional testing.

Reference
  1. Ertle, Christoph M., et al. "New pathways for the skin's stress response: the cholinergic neuropeptide SLURP-1 can activate mast cells and alter cytokine production in mice." Frontiers in immunology 12 (2021): 631881. Under Open Access license CC BY 4.0, without modification. https://doi.org/10.3389/fimmu.2021.631881
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