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NativeExtract™ Recombinant Full Length Human ACHA7 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW259)

Datasheet
This product is recombinant Human ACHA7 protein in native nanodisc form. The synthetic compound we developed can solubilize the ACHA7 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACHA7
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 56.4 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ACHA7
  • Full Name
  • Cholinergic Receptor Nicotinic Alpha 7 Subunit
  • Introduction
  • The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • Cholinergic Receptor Nicotinic Alpha 7 Subunit; Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7; Cholinergic Receptor, Nicotinic, Alpha 7 (Neuronal); Cholinergic Receptor, Nicotinic Alpha 7; NACHRA7; Neuronal Acetylcholine Receptor Protein, Alpha-7 Chain; Acetylcholine Receptor, Nicotinic, Alpha 7 (Neuronal)

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