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CXCR1

Products

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Background

C-X-C motif chemokine receptor 1 (CXCR1) is a class A rhodopsin-like G protein-coupled receptor (GPCR), which is predominantly couples with heterotrimeric Gi proteins upon agonist engagement, leading to phospholipase C activation, intracellular calcium mobilization, and downstream activation of mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3–kinase (PI3K)/AKT pathways. In homeostatic environments, CXCR1-mediated trafficking is required to rapidly contain pathogens and repair damaged tissues. However, in chronic disease, dysregulated CXCR1 signalling promotes tissue destruction in acute respiratory distress syndrome and neutrophil extracellular trap formation in autoimmune vasculitis, driving the recruitment of protumoural neutrophils and myeloid-derived suppressor cells into the breast, pancreatic, and colorectal carcinoma tumour microenvironment. The clinical validation of CXCR1 as a pharmacologically tractable target, bolstered by preclinical efficacy of receptor antagonists in inflammatory and oncological models, has created greater need for structurally authentic ligand-free receptor preparations, pharmacologically faithful cell lines and conformation-specific antibodies to inform modern drug discovery.

Fig.1 CXCR1/2 pathways. (OA Literature)Fig.1 The downstream effectors of pathways elicited by the activation of CXCR1/2 by their respective ligands.1

CXCR1 Protein Function: A Chemotactic Command Center for Neutrophils and Beyond

CXCR1 has a functional reach across multiple interrelated physiological and pathological landscapes:

  • Commander of acute inflammation: CXCR1 sets sharp chemotactic gradients which direct blood neutrophils into tissues infected or injured within minutes from insult (h) That its ability to elicit both rapid morphogenesis and long-lasting directional migration, guarantees that microbial invaders are met with a powerful phagocytic-oxidative arsenal upon the first line of innate immune defense.
  • Tumor Microenvironment Sculptor: CXCR1 expression on neutrophils and myeloid-derived suppressor cells (MDSCs) within malignant tissues enables targeted recruitment towards tumor-derived CXCL8, followed by secretion of arginase, reactive oxygen species (ROS), matrix metalloproteinases which inhibit the function of cytotoxic T-cells whilst fostering metastatic seeding. Pharmacological blockade of this axis reorients the tumor microenvironment to an immune permissive state.
  • Therapeutic Biomarker & Drug Target: High circulating CXCL8 plasma levels and higher tumor-infiltrating neutrophils expressing CXCR1 are associated with poor prognosis in many solid malignancies and resistance to checkpoint inhibition. New precision intervention tools are advancing through preclinical pipelines in the form of small-molecule antagonists and monoclonal antibodies that block CXCR1-mediated signaling for inflammatory disorders and combination immuno-oncology strategies.

CXCR1 Membrane Protein Product

Drive your research on GPCRs and inflammation with our thoroughly characterized recombinant CXCR1 membrane protein product line. We acknowledge that the challenges of producing CXCR1 are considerable due to its seven-transmembrane structure, ligand-dependent conformational flexibility and low natural abundance. We express in multi-platform the well-folded membrane integrated CXCR1 and provide both full-length wild type human CXCR1 exhibitCXCR1 variants from mouse origin; as well N-terminal domain mutants and signaling-deficient CXCR1mutants. Over the last few years, we have validated all preparations biophysically using SDS-PAGE, analytical size-exclusion chromatography and ligand-binding assays to make sure they are suitable for structural biology, antibody screening and drug discovery.

CXCR1 Protein Product

Not finding the membrane protein product you need? Contact us to start your one-stop custom service!

CXCR1 Stable Cell Line Product

We offer stable cell lines expressing either wild-type or modulated levels of human, mouse and rat CXCR1, using both endogenous receptor expression systems for loss-of-function studies. These platforms optimize conditions to achieve the high-throughput calcium mobilization assays, chemotaxis quantification, NET formation studies and cancer stem cell sphere formation assays that support the experimental consistency necessary for multi-phase research initiatives.

CXCR1 Stable Cell Line Product

Not finding the stable cell line product you need? Contact us to start your one-stop custom service!

CXCR1 Recombinant Antibody Product

We offer a broad range of high-affinity recombinant antibodies against CXCR1 for an array of research applications. Using cutting-edge recombinant technologies, these antibodies provide greater specificity, sensitivity, and batch-to-batch consistency than polyclonal antibodies. Our CXCR1 recombinant antibodies are validated for a range of applications, including WB, ELISA, FCM, IHC and IP on various samples from neutrophil cell lysate to tumor biopsy to transfected cell membranes.

CXCR1 Recombinant Antibody Product

Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!

Product Features

  • High Purity & Activity: High purity and verified integrity for dependable downstream work.
  • Diverse Expression Systems: Choice of expression formats to match routine or specialized projects.
  • Species Reactivity: Products available for human, mouse, pig, and other species.
  • Validated Applications: Application-tested to deliver consistent signals across common lab workflows.
  • Exceptional Lot-to-Lot Consistency: Tight lot-to-lot control for reproducible performance.
  • Customization Options: Flexible customization of tags, labels, or packaging upon request.

Custom CXCR1 Membrane Protein and Antibody Discovery Services

In addition to our catalog products, we provide custom services for membrane protein and antibody discovery and development. Drawing on our deep expertise in GPCR biology and chemokine receptor pharmacology, we can provide you with:

  • Custom CXCR1 Receptor Production: Tailored expression, purification, and characterization of challenging multi-domain receptor constructs.
  • Custom Antibody Development: From antigen design to antibody engineering (monoclonal, polyclonal, recombinant) for specific research applications.
  • Stable Cell Line Development: Generation of bespoke stable cell lines expressing your target of interest.
  • Functional Assay Development: Designing and executing assays to assess receptor activation and ligand.

Frequently Asked Questions (FAQ)

  1. What products do you have for CXCR1?

    We can provide various products, such as recombinant full-length CXCR1; N-terminal domain fragments of CXCR1; stable cell lines with expression of CXCR1 or the downstream signaling components.

  2. What are the species variants that exist?

    Our catalog includes mouse, and rat CXCR1 reagents. Additional orthologs or engineered mutants, including GRK2-uncoupled variants and constitutively active mutants, can be made available upon request.

  3. Do you have stable cell lines to express CXCR1 on demand or combined with CXCR2?

    Absolutely. Our cell engineering team regularly engineers tetracycline-inducible systems and lines that co-express CXCR1 together with CXCR2, Gαi or calcium biosensors for global pathway analysis and examination of receptor selectivity. We welcome in detail discussions on your expression architecture and phenotypic needs.

  4. Are your CXCR1 products intended for clinical or diagnostic use?

    No, all CXCR1 products and services are for research use only and not for clinical diagnosis, prevention, treatment or cure of any disease.

Reference
  1. Molczyk, Caitlin, and Rakesh K. Singh. "CXCR1: A cancer stem cell marker and therapeutic target in solid tumors." Biomedicines 11.2 (2023): 576. Under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/biomedicines11020576
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