Introduction of AQP1
AQP1 is also known as Aquaporin-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule. It belongs to the Aquaporins (AQPs) family which is a class of channel protein and is expressed in the plasma membrane of bacteria, plant, and animal cells. AQP1 is identified from human red blood cell membranes by Gheorghe Benga's research group in 1986 for the first time. AQP1 has six membrane-spanning domains and two domains that partially insert into the membrane (M1–M8), forming an amino acid-lined pore down the center of the protein.
|Basic Information of AQP1|
|Aliases||Aquaporin-1, Aquaporin-CHIP, Urine water channel|
|Organism||Homo sapiens (Human)|
Function of AQP1 Membrane Protein
AQP1 channels in the major intrinsic protein (MIP) family mediate water movement across membranes by a transmembrane osmotic gradient in the brain, kidney, vascular system, and other tissues. So, AQP1 is also known as water channels. AQP1 knockout mice have impaired urine concentration, reduced water movement across the peritoneum and lung microvessels. In the brain, AQP1 participates in the generation of cerebrospinal fluid. Besides, the site of AQP1 expression may be an important determinant of its role in myocardial water balance in health and disease. For example, if AQP1 is expressed in cardiomyocytes, it may facilitate water accumulation and clearance from these cells. If it is found in endothelial cells, it may mediate water flux between the vasculature and the interstitium. In addition, the increased activity of AQP1 in the presence of PKC may contribute to the stimulation of physiological processes that are modulated by AQP1 such as endothelial permeability, angiogenesis, and urea concentration.
Fig.1 Structure of AQP1 membrane protein.
Application of AQP1 Membrane Protein in Literature
This article reviews the role of AQP1, the genetics of AQP1 and mutations in cell migration and angiogenesis in relation with cancer. Meanwhile, the role of AQP1 in red blood cells is discussed based on the comparative studies of water permeability in over 30 species.
This article describes a novel pathway in mammalian cells whereby a hypotonic stimulus directly induces intracellular calcium elevations through transient receptor potential channels, which trigger AQP1 translocation.
The data of this article demonstrate that AQP1 is a direct target of Mef2c in regulating angiogenesis and vasculogenesis of endothelial cells.
This article concludes that AQP1 is a major regulator of the platelet procoagulant response, able to modulate coagulation after injury or pathologic stimuli without affecting other platelet functional responses or normal hemostasis.
This article suggests that AQP1 could be adjusted by Erk1/2 signaling. Moreover, the inhibitory effect of AA-I on AQP1 was stronger than that of TGF-β1, suggests that AQP1 may be an important target on AAN clinical therapy.
AQP1 Preparation Options
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