Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | F2R like trypsin receptor 1 |
| Gene Name | F2RL1 |
| Uniprot | P55085 (Human); P55086 (Mouse) |
| Synonym | PAR2; GPR11; proteinase-activated receptor 2; G-protein coupled receptor 11; coagulation factor II (thrombin) receptor-like 1; protease-activated receptor 2; thrombin receptor-like 1 |
| Background | F2RL1, also referred as PAR2 (protease activated receptor 2) or GPR11 (G-protein coupled receptor 11), is a protein product as a member of the G-protein coupled receptor family, as well as the protease-activated receptor family, encoded by the F2RL1 gene. It is noteworthy that the protein can be activated by trypsin, but not by thrombin. It has been demonstrated that activation of the receptor is associated with stimulation of vascular smooth muscle relaxation, dilation of blood vessels, increase of blood flow, and a lowering of blood pressure. In addition, this protein plays an important role in both inflammatory response and innate and adaptive immunity. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX469 | NativeExtract™ Human F2RL1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0723-KX161 | MemDX™ Recombinant Human F2RL1 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX3451K | MemDX™ Membrane Protein Human F2RL1 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0345X | MemDX™ Membrane Protein Human F2RL1 (F2R like trypsin receptor 1) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| S01YF-0423-KX598 | MemDX™ Membrane Protein Human F2RL1 (37-71aa) Expressed in HEK293, C-Human Fc tag | HEK293 cells | Partial | N/A |
| Please contact us for more products or customization | ||||
Q***n: I recently purchased the F2RL1 protein from Creative Biolabs, and I must say, I am extremely satisfied with my experience.
06/Feb/2023
N*x: The customer support team was very responsive and helpful, providing detailed information and guidance whenever I needed it.
15/Aug/2023
We provide tailored solutions to meet your specific requirements. Please inquire us for more services.
Viral Vectors
Creative Biolabs offers viral vectors development services. The precise delivery of genetic material into eukaryotic cells constitutes a foundational pillar of contemporary molecular biology and therapeutic intervention. Within this paradigm, viral vectors, notably those derived from adenovirus, adeno-associated virus (AAV), lentivirus, and retrovirus, frequently serve as indispensable conduits for the efficient transduction of target cell populations. These sophisticated biological vehicles possess an intrinsic capacity to convey exogenous genetic sequences, such as the human F2RL1 gene, with remarkable proficiency into host cellular machinery.
Non-viral Vectors
Creative Biolabs offers non-viral vectors development services. The fundamental unit of non-viral gene delivery, plasmid DNA, can be precisely introduced into target cellular populations through a spectrum of physical and chemical approaches. For instance, electroporation, which transiently permeabilizes cell membranes via an applied electrical field, and lipofection, involving the formation of lipid-DNA complexes that fuse with the cell membrane, are frequently employed techniques to facilitate the cytoplasmic or nuclear entry of these genetic constructs. Furthermore, sophisticated delivery vehicles such as nanoparticles and liposomes are increasingly harnessed for their capacity to encapsulate and protect the desired genetic payload, such as the F2RL1 gene, thereby significantly enhancing its targeted cellular uptake.
Gene Regulation and Expression Control
Creative Biolabs offers gene regulation and expression control services. The judicious selection of a promoter element stands as a paramount consideration in regulating the spatiotemporal expression profile of any transgenic construct, including, notably, the F2RL1 gene. This critical regulatory sequence dictates the transcriptional initiation of the downstream genetic material, thereby exerting precise control over its cellular abundance. The deployment of tissue-specific promoters represents a sophisticated strategy to ensure that the F2RL1 gene is transcribed exclusively within the intended cellular milieu or specific tissue architecture. This targeted approach is not merely an exercise in specificity; rather, it is a fundamental design principle aimed at mitigating potential pleiotropic effects or undesired physiological consequences that might arise from ectopic gene expression in off-target tissues.
Creative Biolabs offers comprehensive and innovative services to drive the development of F2RL1 cell therapy. Please inquire with us for more services.
Overexpression and Functional Assays
Creative Biolabs offers overexpression and functional assay services. To elucidate the biological significance of the F2RL1 protein, it is imperative to manipulate its cellular abundance experimentally. This typically involves the forced expression of the F2RL1 gene within target cellular systems, a feat commonly achieved through the strategic deployment of various gene delivery vectors or other sophisticated transfection methodologies. Following successful overexpression, a suite of meticulous functional assays becomes indispensable for a comprehensive appraisal of the downstream effects on cellular physiology.
Animal Models
Creative Biolabs offers animal model development services. To thoroughly elucidate the multifaceted physiological and pathological roles of the F2RL1 gene, the generation and meticulous analysis of genetically engineered murine models are indispensable. This experimental strategy commonly involves the creation of constitutive F2RL1 knockout mice, wherein the gene is entirely abrogated across all tissues and developmental stages. Such models afford a comprehensive, albeit broad, understanding of the complete loss-of-function phenotype associated with F2RL1 deficiency. The insights gleaned from these sophisticated models are critical for advancing our understanding of this particular gene's role in health and disease.
In Vivo Functional Validation
Creative Biolabs offers in vivo functional validation services. The transition from in vitro mechanistic insights to a comprehensive understanding of therapeutic potential necessitates rigorous in vivo experimentation. Consequently, to substantiate the putative therapeutic efficacy of F2RL1-targeted cellular interventions, it becomes imperative to conduct meticulously designed animal studies. This evidence is indispensable for advancing these promising approaches towards clinical translation.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
