Introduction of F2RL1
F2RL1, also referred as PAR2 (protease activated receptor 2) or GPR11 (G-protein coupled receptor 11), is a protein product as a member of the G-protein coupled receptor family, as well as the protease-activated receptor family, encoded by the F2RL1 gene. It is noteworthy that the protein can be activated by trypsin, but not by thrombin. It has been demonstrated that activation of the receptor is associated with stimulation of vascular smooth muscle relaxation, dilation of blood vessels, increase of blood flow, and a lowering of blood pressure. In addition, this protein plays an important role in both inflammatory response and innate and adaptive immunity.
|Basic Information ofF2RL1|
|Protein Name||Proteinase-activated receptor 2|
|Organism||Homo sapiens (Human)|
Function of F2RL1 Membrane Protein
PAR2 is activated by proteolytic cleavage of its extracellular amino terminus. Activation of the receptor contributes to stimulating vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. PAR2 takes part in the recruitment of leukocytes to the sites of inflammation and serves as the major PAR receptor. Additionally, these receptors can be activated by exogenous proteases, such as house dust mite protein Der P9.
Application of F2RL1 Membrane Protein in Literature
This article reveals that PAR-2 signaling activates macrophages and promotes vascular inflammation, increasing atherosclerosis in ApoE-/- mice. This signaling pathway may also participate in atherogenesis in humans.
This article shows that PAR-2 has been involved in the pathogenesis of osteoarthritis (OA).
This article suggests that PAR2 plays an important role in the proliferation and metastasis of hepatocellular carcinoma. Therefore, targeting PAR2 may present a favorable target for treatment of this malignancy.
This article suggests that cigarette smoke extract (CSE) upregulates PAR2 in normal human bronchial epithelial cells, thereby enhancing the inflammatory response to NE.
F2RL1 Preparation Options
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