Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | G protein-coupled receptor class C group 5 member A |
| Gene Name | GPRC5A |
| Uniprot | Q8NFJ5 (Human); Q8BHL4 (Mouse) |
| Synonym | RAI3; TIG1; RAIG1; GPCR5A; PEIG-1; retinoic acid-induced protein 3; G-protein coupled receptor family C group 5 member A; TPA induced gene 1; orphan G-protein-coupling receptor PEIG-1; phorbol ester induced gene 1; phorbol ester induced protein-1; retinoic acid induced 3; retinoic acid responsive; retinoic acid-induced gene 1 protein |
| Background | Retinoic acid-induced protein 3 (GPRC5A) is a protein that in humans is encoded by the GPRC5A gene. GPRC5A is one of the few genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR. GPRC5A is a member of the type 3 G protein-coupling receptor family, which is characterized by the signature 7-transmembrane domain motif. Gene Ontology (GO) annotations related to GPRC5A include G-protein coupled receptor activity. An important paralog of this gene is GPRC5D. GPRC5A is an orphan receptor that may be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provides evidence for possible interactions between retinoid and G-protein signaling pathways. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX59 | NativeExtract™ Human GPRC5A Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3439K | MemDX™ Membrane Protein Human GPRC5A Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0630J | MemDX™ Membrane Protein Human GPRC5A (G protein-coupled receptor class C group 5 member A) for Antibody Discovery | HEK293 cells | Full length | N/A |
| MP0480X | MemDX™ Membrane Protein Human GPRC5A with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0479X | MemDX™ Membrane Protein Human GPRC5A without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| S01YF-0423-KX587 | MemDX™ Membrane Protein Human GPRC5A (1-33aa) Expressed in HEK293, C-Mouse Fc tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
W**n: Reliable batch-to-batch reproducibility and responsive technical support ensure seamless experimental workflows.
09/Nov/2023
A*h: Customized GPRC5A variants delivered rapid turnaround functional validation data. Ideal for high-throughput screening and structural studies.
17/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers knockout services. Gene editing approaches represent a cornerstone in GPRC5A-targeted gene therapy, enabling precise disruption of the receptor to elucidate its role in disease pathogenesis. For instance, RNAs designed against exon regions of GPRC5A facilitate frameshift mutations, effectively abolishing receptor function in preclinical models of metabolic disorders. Empirical studies demonstrate that GPRC5A knockout in hepatic cell lines significantly attenuates lipid accumulation, underscoring its therapeutic relevance in non-alcoholic fatty liver disease (NAFLD). Creative Biolabs' proprietary optimization platforms ensure high-specificity editing, minimizing off-target effects while maximizing translational potential.
Creative Biolabs offers AAV-driven overexpression services. AAV vectors engineered to deliver GPRC5A cDNA under tissue-specific promoters offer a promising strategy to counteract tumor-suppressive loss observed in certain carcinomas. In lung adenocarcinoma models, intratumoral AAV-mediated GPRC5A overexpression has been shown to inhibit proliferation by reactivating pro-apoptotic signaling pathways. Creative Biolabs' expertise in designing cell-selective AAV serotypes ensures targeted delivery to malignant epithelia, enhancing therapeutic efficacy while sparing healthy tissues. This approach aligns with emerging paradigms in precision oncology, where restoring endogenous tumor suppressor activity is prioritized.
Creative Biolabs offers base editing services. Single-nucleotide polymorphisms (SNPs) in GPRC5A's regulatory regions have been linked to altered receptor trafficking and signaling. Base editing technologies, such as adenine deaminase-coupled systems, enable precise correction of these pathogenic variants without inducing double-strand breaks. For example, G→A conversions in the promoter region restore transcriptional activity in pancreatic β-cell models, potentially ameliorating diabetes-associated dysregulation. Creative Biolabs' validated SNP screening pipelines and bespoke editing solutions empower researchers to advance such allele-specific therapies efficiently.
Creative Biolabs offers comprehensive and innovative services to drive the development of GPRC5A cell therapy. Please for more services.
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting GPRC5A-expressing tumor cells exploit the receptor's unique overexpression in select malignancies. Preclinical data reveal that GPRC5A-specific CAR-T cells induce potent cytotoxic responses in triple-negative breast cancer models, bypassing immune evasion mechanisms mediated by checkpoint ligands. Creative Biolabs' tailored lentiviral vector systems streamline CAR construct integration, ensuring robust T-cell activation and persistence. Coupled with advanced immunofluorescence validation services, this platform accelerates translational readiness.
Creative Biolabs offers stem cell-derived secretome modulation services. Induced pluripotent stem cells (iPSCs) engineered to overexpress GPRC5A secrete paracrine factors that promote tissue repair in ischemic injury models. In myocardial infarction studies, GPRC5A-enriched iPSC-derived exosomes enhance angiogenesis by upregulating VEGF-A synthesis. Creative Biolabs' end-to-end cell therapy workflows, including viral vector design and functional proteomic profiling, enable rapid optimization of such regenerative strategies.
Creative Biolabs offers oncolytic virus vectors development services. Engineered oncolytic viruses incorporating GPRC5A-specific promoters achieve dual lytic and immunomodulatory effects in glioma models. These vectors selectively replicate within GPRC5A-positive tumor cells, inducing immunogenic cell death while sparing neural progenitors. Creative Biolabs' expertise in viral tropism refinement ensures maximal tumor specificity, a critical factor in mitigating neurotoxicity risks.
The integration of cutting-edge gene and cell therapy modalities demands precision tools and domain-specific expertise. Creative Biolabs' comprehensive portfolio provides the foundation for transformative GPRC5A-targeted therapies. to explore tailored solutions that align with your therapeutic objectives. Leverage our two decades of antibody and protein engineering mastery to accelerate your pipeline from discovery to clinical impact.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
