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MemDX™ Recombinant Full Length Human MCOLN3 Protein (Nanodisc, Rho1D4 Tag) (CAT#: SYF-0926-CW139)

Recombinant full-length human MCOLN3 protein reconstituted in a nanodisc membrane-mimetic system for biochemical, binding, and assay development applications.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • MCOLN3
  • Protein Length
  • Full-length
  • Protein Class
  • TRP Ion Channel
  • Molecular Weight
  • 64 kDa (homotetramer)
  • Sequence
  • MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK

Product Description

  • Expression Systems
  • HEK293 cells
  • Tag
  • The construct includes a C-terminal Rho1D4 tag.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • MCOLN3
  • Full Name
  • mucolipin TRP cation channel 3
  • Introduction
  • Mucolipin-3 (MCOLN3) is a full-length human ion channel. Mucolipin-3 is a TRPMC channel, which is involved in the regulation of membrane trafficking as well as the regulation of intercellular Ca2+ signalling and it mediates the release of Ca from endosomes into the cytoplasm and contributes to endosomal acidification. It is also permeable to further cations, such as Mg, Na and K. Furthermroe, MCOLN3 contributes to autophagosome biogenesis. The protein is supplied in an MSP-free, copolymer-stabilized native-lipid nanodisc. The preparation uses 2-step purification.
  • Alternative Names
  • TRPML3, FLJ11006, TRP-ML3

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