Protein Structure Modeling Service

Protein structure modeling is a powerful and promising approach for protein engineering and further drug design. After years of efforts, Creative Biolabs has successfully established an advanced protein platform and computation technology to offer a full range of protein structure modeling services with the highest quality.

Background of Protein Structure Modeling

Protein structure modeling is to predict the three-dimensional (3D) structure of a protein by computational modeling from its primary amino acid sequence. As known to all, normal protein functions are determined by their tertiary or quaternary structure, rather than amino acid sequences. Therefore, protein 3D structure modeling can provide essential information and predict biological functions, which is significant and meaningful to protein engineering and application for therapeutic drug design. So, the reasons why protein 3D structure modeling has received so much attention may include as follows:

The quantity of identified proteins, particularly the number of protein sequences, increases sharply resulting from the advent of advanced DNA sequencing technology. There are more than 100 million protein sequences in the UniProt/TrEMBL database up to now.
It is more intuitive and convenient to directly compare the structures of gene products since the 3D structure of a protein reveals biological functions information.
Previous experimental determination methods, such as X-ray crystallography, nuclear magnetic resonance spectroscopy, cryogenic electron microscopy, are expensive and time-consuming, which unable to satisfy the need for protein structure determination on a large scale.

Fig.1 Three-dimensional protein structure prediction. (Dorn, 2014)

Service

Over decades of exploration, numbers of approaches and computational algorithms have been attempted and developed for protein structure modeling, such as homology modeling, integrative modeling, threading, etc. Creative Biolabs here provides a wide range of advanced structure modeling services for various protein sequences.

Comparative Protein Structure Modeling

Protein structure comparative modeling, also termed as template-based modeling, is the most commonly used and reliable computational modeling approach based on one or more recognized homologous protein templates sharing highly similar sequences. Comparative modeling is our popular service, which has assisted many customers to predict the structure of proteins in various monomeric and oligomeric forms.

De Novo Modeling

De novo modeling is a newly-developed protein structure modeling method that can be utilized whether there is an identified template or not. But the limitation of this computational method is that it is only applicable to smaller protein sequences. Creative Biolabs provides comprehensive De novo modeling services based on the well-constructed computational platform.

Integrative (Hybrid) Modeling

Integrative modeling or hybrid modeling is a comprehensive protein structure modeling to figure out the components and interactions of the protein of interest. By vast quantities of information input, integrative modeling is a computational technique for characterizing the structures of protein assemblies with high efficiency and accuracy. We are proud to be the integrative modeling services provider for the protein structure prediction.

Creative Biolabs is specialized in structure modeling and harbors extensive experience in protein engineering using our comprehensive platforms. We leverage the leading computational techniques to provide various protein structure modeling services to global clients. If you are interested in our services, contact us to discuss your requirements.

Reference

Dorn, M.; et al. Three-dimensional protein structure prediction: Methods and computational strategies. Computational Biology and Chemistry. 2014, 53PB: 251-276.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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