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NativeExtract™ Recombinant Full Length Human SCN8A Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW158)

This product is recombinant Human SCN8A protein in native nanodisc form. The synthetic compound we developed can solubilize the SCN8A protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SCN8A
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 225.3 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • SCN8A
  • Full Name
  • Sodium Voltage-Gated Channel Alpha Subunit 8
  • Introduction
  • This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • Sodium Voltage-Gated Channel Alpha Subunit 8; Sodium Channel, Voltage Gated, Type VIII, Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.6; MED; Sodium Channel, Voltage Gated, Type VIII, Alpha Polypeptide; Sodium Channel, Voltage Gated, Type VIII Alpha Subunit; Voltage-Gated Sodium Channel Type VIII Alpha Protein; Sodium Channel Protein Type VIII Subunit Alpha; Sodium Channel Protein Type 8 Subunit Alpha

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