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MemDX™ Recombinant Full Length Human CCR5 Protein, Biotinylated Nanodisc (CAT#: SYF-0926-CW70)

Recombinant full-length human CCR5 protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CCR5
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 45 kDa
  • Sequence
  • DYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes C-terminal Strep and Rho1D4 tags. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • CCR5
  • Full Name
  • C-C motif chemokine receptor 5
  • Introduction
  • C-C chemokine receptor type 5 (CCR5) is a full-length human gpcr. C-C chemokine receptor type 5 is a receptor for different inflammatory CC-chemokines and is involved in the T-lymphocyte migration to the infectory site by acting as a chemotactic receptor. Thereby, it is involved in inflammatory reactions. Moreover, it is the coreceptor of human immunodeficiency virus 1 (HIV) and a target for HIV entry inhibitors. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • CKR-5, CC-CKR-5, CKR5, CD195, IDDM22, CMKBR5

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