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NativeExtract™ Recombinant Full Length Human CLCA2 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW235)

This product is recombinant Human CLCA2 protein in native nanodisc form. The synthetic compound we developed can solubilize the CLCA2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLCA2
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 103.9 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLCA2
  • Full Name
  • Chloride Channel Accessory 2
  • Introduction
  • This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines.
  • Alternative Names
  • Chloride Channel Accessory 2; Chloride Channel, Calcium Activated, Family Member 2; Calcium-Activated Chloride Channel Protein 3; CaCC-3; CACC3; Calcium-Activated Chloride Channel Family Member 2; CLCA Family Member 2, Chloride Channel Regulator; Calcium-Activated Chloride Channel Regulator 2

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