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NativeExtract™ Recombinant Full Length Human CAC1C Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW178)

This product is recombinant Human CAC1C protein in native nanodisc form. The synthetic compound we developed can solubilize the CAC1C protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CAC1C
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 249 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CAC1C
  • Full Name
  • Calcium Voltage-Gated Channel Subunit Alpha1 C
  • Introduction
  • This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.
  • Alternative Names
  • Calcium Voltage-Gated Channel Subunit Alpha1 C; Calcium Channel, L Type, Alpha-1 Polypeptide, Isoform 1, Cardiac Muscle; Calcium Channel, Voltage-Dependent, L Type, Alpha 1C Subunit; CACNL1A1; CCHL1A1; CACH2; CACN2; Voltage-Gated L-Type Calcium Channel Cav1.2 Alpha 1 Subunit, Splice Variant 10*; Calcium Channel, Cardic Dihydropyridine-Sensitive, Alpha-1 Subunit

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