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NativeExtract™ Recombinant Full Length Human TREM2 Protein (Nanodisc, FLAG-tagged) (CAT#: SYF-0426-CW11)

This product is recombinant Human TREM2 protein in native nanodisc form. The synthetic compound we developed can solubilize the TREM2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TREM2
  • Protein Length
  • Full length
  • Protein Class
  • Immune Checkpoint Inhibitor
  • Molecular Weight
  • 25.4 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • TREM2
  • Full Name
  • Triggering Receptor Expressed On Myeloid Cells 2
  • Introduction
  • This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • AD17; PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c

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