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MemDX™ Recombinant Full Length Human CLDN18.1 Protein (Biotinylated Nanodisc, Rho1D4 Tag) (CAT#: SYF-0926-CW90)

Recombinant full-length human CLDN18.1 protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLDN18.1
  • Protein Length
  • Full-length
  • Protein Class
  • Tight Junction Protein
  • Molecular Weight
  • 28 kDa
  • Sequence
  • MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

Product Description

  • Expression Systems
  • HEK293 cells
  • Tag
  • The construct includes a C-terminal Rho1D4 tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • CLDN18.1
  • Full Name
  • claudin 18
  • Introduction
  • Claudin-18.1 (isoform 1) (CLDN18.1) is a full-length human claudin. Claudin-18.1 is the lung-specific isoform of claudin-18. It is involved in tight junction and barrier formation in the lung epithelium, but also in mediating the osteoprotective effects of oestrogen. It has been identified as a regulator of lung homeostasis and is also involved in the proliferation of malignant cells found in lung adenocarcinomas, which makes it a potential therapeutic target in cancer. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • SFTPJ

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