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MemDX™ Recombinant Full Length Human CLDN4 Protein (Biotinylated Nanodisc, Rho1D4 Tag) (CAT#: SYF-0926-CW98)

Recombinant full-length human CLDN4 protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLDN4
  • Protein Length
  • Full-length
  • Protein Class
  • Tight Junction Protein
  • Molecular Weight
  • 22 kDa
  • Sequence
  • MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV

Product Description

  • Expression Systems
  • HEK293 cells
  • Tag
  • The construct includes a C-terminal Rho1D4 tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • CLDN4
  • Full Name
  • claudin 4
  • Introduction
  • Claudin-4 (CLDN4) is a full-length human claudin. Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • CPE-R, WBSCR8, hCPE-R, CPETR, CPETR1

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