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NativeExtract™ Recombinant Full Length Human CRFM7 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW249)

Datasheet
This product is recombinant Human CRFM7 protein in native nanodisc form. The synthetic compound we developed can solubilize the CRFM7 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CRFM7
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 46.2 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CRFM7
  • Full Name
  • CHRNA7 (Exons 5-10) And FAM7A (Exons A-E) Fusion
  • Introduction
  • The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.
  • Alternative Names
  • CHRNA7 (Exons 5-10) And FAM7A (Exons A-E) Fusion; CHRNA7 (Cholinergic Receptor, Nicotinic, Alpha 7, Exons 5-10) And FAM7A (Family With Sequence Similarity 7A, Exons A-E) Fusion; CHRNA7-DR1; D-10; CHRNA7 (Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7, Exons 5-10) And FAM7A (Family With Sequence Similarity 7A, Exons A-E) Fusion; Alpha 7 Neuronal Nicotinic Acetylcholine Receptor-FAM7A Hybrid; Alpha-7 Nicotinic Cholinergic Receptor Subunit; CHRNA7-FAM7A Fusion Protein; CHRNA7

Case Studies

Customer reviews and Q&As    

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