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NativeExtract™ Recombinant Full Length Human KCTD1 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW164)

This product is recombinant Human KCTD1 protein in native nanodisc form. The synthetic compound we developed can solubilize the KCTD1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCTD1
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 29.4 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • KCTD1
  • Full Name
  • Potassium Channel Tetramerization Domain Containing 1
  • Introduction
  • This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome.
  • Alternative Names
  • Potassium Channel Tetramerization Domain Containing 1; C18orf5; Potassium Channel Tetramerization Domain-Containing Protein 1; Potassium Channel Tetramerisation Domain Containing 1; BTB/POZ Domain-Containing Protein KCTD1

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