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NativeExtract™ Recombinant Full Length Human GLRB Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW72)

This product is recombinant Human GLRB protein in native nanodisc form. The synthetic compound we developed can solubilize the GLRB protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GLRB
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 56.1 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GLRB
  • Full Name
  • Glycine Receptor Beta
  • Introduction
  • This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • Glycine Receptor Beta; Glycine Receptor 58 KDa Subunit; Glycine Receptor, Beta Subunit; Glycine Receptor Subunit Beta; HKPX2

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