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NativeExtract™ Recombinant Full Length Human NMDE2 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW139)

Datasheet
This product is recombinant Human NMDE2 protein in native nanodisc form. The synthetic compound we developed can solubilize the NMDE2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NMDE2
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 166.4 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • NMDE2
  • Full Name
  • Glutamate Ionotropic Receptor NMDA Type Subunit 2B
  • Introduction
  • This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.
  • Alternative Names
  • Glutamate Ionotropic Receptor NMDA Type Subunit 2B; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B; Glutamate [NMDA] Receptor Subunit Epsilon-2; N-Methyl D-Aspartate Receptor Subtype 2B; N-Methyl-D-Aspartate Receptor Subunit 3; NMDAR2B; GluN2B; NR2B

Case Studies

Customer reviews and Q&As    

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