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MemDX™ Recombinant Full Length Human OPRM1 Protein (Nanodisc, Rho1D4 Tag & FLAG Tag) (CAT#: SYF-0926-CW147)

Recombinant full-length human OPRM1 protein reconstituted in a nanodisc membrane-mimetic system for biochemical, binding, and assay development applications.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • OPRM1
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 47 kDa
  • Sequence
  • DSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes an N-terminal FLAG tag and a C-terminal Rho1D4 tag.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • OPRM1
  • Full Name
  • opioid receptor mu 1
  • Introduction
  • Mu-type opioid receptor (OPRM1) is a full-length human gpcr. G-protein coupled opioid receptor that functions as a primary receptor for endogenous beta-endorphins and enkephalins, but has lower affinity for dynorphins. It also functions as the principal receptor for various synthetic opioids (such as morphine, fentanyl, and oxycodone) and for the competitive antagonist naloxone. Beyond analgesia, it play a critical role in regulating autonomic and physical functions, including the modulation of respiratory rate, gastrointestinal motility, and the neuroendocrine stress response. The protein is supplied in an MSP-free, copolymer-stabilized native-lipid nanodisc. The preparation uses 2-step purification.
  • Alternative Names
  • MOR1, MOP

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