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NativeExtract™ Recombinant Full Length Human PLM Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW22)

Datasheet
This product is recombinant Human PLM protein in native nanodisc form. The synthetic compound we developed can solubilize the PLM protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PLM
  • Protein Length
  • Full length
  • Protein Class
  • Immune Checkpoint Inhibitor
  • Molecular Weight
  • 10.4 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • PLM
  • Full Name
  • FXYD Domain Containing Ion Transport Regulator 1
  • Introduction
  • This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.
  • Alternative Names
  • FXYD Domain Containing Ion Transport Regulator 1; Sodium/Potassium-Transporting ATPase Subunit FXYD1; Phospholemman; PLM; FXYD Domain-Containing Ion Transport Regulator 1

Case Studies

Customer reviews and Q&As    

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