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NativeExtract™ Recombinant Full Length Human SCAP Protein (Nanodisc, FLAG-tagged) (CAT#: SYF-0426-CW5)

This product is recombinant Human SCAP protein in native nanodisc form. The synthetic compound we developed can solubilize the SCAP protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SCAP
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 139.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • SCAP
  • Full Name
  • SREBF Chaperone
  • Introduction
  • This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants.

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