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NativeExtract™ Recombinant Full Length Human SCN7A Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW90)

Datasheet
This product is recombinant Human SCN7A protein in native nanodisc form. The synthetic compound we developed can solubilize the SCN7A protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SCN7A
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 193.5 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • SCN7A
  • Full Name
  • Sodium Voltage-Gated Channel Alpha Subunit 7
  • Introduction
  • This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown.
  • Alternative Names
  • Sodium Voltage-Gated Channel Alpha Subunit 7; Sodium Channel Protein Cardiac And Skeletal Muscle Subunit Alpha; Putative Voltage-Gated Sodium Channel Subunit Alpha Nax; Sodium Channel, Voltage-Gated, Type VII, Alpha Subunit; Sodium Channel Protein Type VII Subunit Alpha; SCN6A; Sodium Channel, Voltage-Gated, Type VI, Alpha Polypeptide; Sodium Channel, Voltage Gated, Type VII Alpha Subunit

Case Studies

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