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Mesenchymal Stem Cells (MSCs) Differentiation Services

Mesenchymal stem cells (MSCs) are undifferentiated multipotent cells that possess great potential in tissue regeneration and cell-based therapy due to their multipotency. Application of MSCs requires their isolation and direction of their differentiation into the appropriate lineage. Creative Biolabs offers customized services for reliable in vitro induction of MSCs into osteogenic, adipogenic, muscular, and chondrogenic lineages.

Differentiation Potential of MSCs

MSCs have the ability to differentiate into a large number of specialized cell types following specific signals (e.g., Wnt and redox signals, microRNAs, reactive oxygen species). These include mesodermal (osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes), ectodermal (neuronal cells) and endodermal (hepatic, pancreatic, respiratory epithelium) lineages. Moreover, a fully differentiated cell from one lineage can switch into another mature cell type of MSCs, which is a phenomenon called genetic reprogramming or transdifferentiation. As a result, MSCs derived from different tissues can be readily isolated and expanded for both basic and biomedical research. It has to be noted that MSCs from different tissues have exhibited differences in their differentiation capacity and regeneration potential. Besides, increased age of donor and passaging of cultured MSCs also decrease differentiation potential.

Differential potential of MSCs. Fig.1 Differential potential of MSCs.

Differentiation into Adipogenic Lineages

The processes by which MSCs commit to the adipose lineage and differentiate into adipocytes is termed adipogenesis. This process is triggered by signaling factors that induce conversion of MSCs to preadipocytes that differentiate into adipocytes. Thereafter, exposure of preadipocytes to differentiation inducers, such as insulin-like growth factor1, glucocorticoid, and cyclic AMP, triggers the expression of adipocyte genes and the production of adipocyte phenotype. With the use of appropriate cultures, Creative Biolabs can help induce the differentiation of your MSCs into both white and brown adipocytes.

Differentiation into Muscular Lineages

Manipulations of MSCs toward muscular lineage differentiation is a focused area in recent years due to the toll of different muscle diseases and a lack of understanding of muscle differentiation and repair mechanism. To help facilitate these research areas, Creative Biolabs offers in vitro skeletal, cardiac, and smooth myogenic induction services of MSCs derived from different tissues. Different supplements (e.g., growth factors, cytokines, and extracellular matrix proteins) are added into the media for differentiation induction and specific marker expression for successful differentiation can be evaluated.

Differentiation into Chondrogenic Lineages

The capabilities of MSCs to differentiate into chondrogenic lineages make it a promising approach for cartilage repair and regeneration. The chondrogenic differentiation of MSCs is regulated by many factors and thus it relies on exposure to specific reagents (mainly inductive morphogens) to push MSCs to develop into specific phenotypes. Creative Biolabs has rich experience in promoting the chondrogenic differentiation of MSCs and enhancing the chondrogenic potential of dedifferentiated chondrocytes.

Features of our Services

Creative Biolabs conducts custom-specific contract research based on years of experience gained in a number of successful development projects. We can provide both individual service modules and full packages of services. Our state-of-the-art technologies and highly-qualified personnel guarantee that we can deliver maximum quality and flexibility in all phases of the product lifecycle. Please feel free to contact us for more information.

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  • Tel: 1-631-381-2994
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