Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
X-C motif chemokine receptor 1 (XCR1) is a seven-transmembrane GPCR glycoprotein encoded by the XCR1 gene, composed of extracellular chemokine ligand-binding loops, transmembrane helical bundle and cytoplasmic G protein coupling tail, and acts as a lineage-specific receptor subunit for cross-presenting dendritic cell chemokine signaling complexes. XCR1 is selectively expressed across conventional type 1 dendritic cell populations within lymphoid tissue, serving as a core scaffold mediating G protein heterotrimer assembly and downstream antigen presentation kinase recruitment upon XCL chemokine stimulation.
XCR1 exerts its biological effects through dynamic G protein coupling assembly upon cognate chemokine binding, a mechanism that stabilizes ligand interaction and modulates intracellular cross-presentation signal cascade activation efficiency. Unlike auxiliary chemokine receptor subunits, XCR1 cannot initiate full antigen presentation signal output without ligand binding and G protein complex formation; it recruits cytoplasmic signal mediators to assembled receptor-G protein complexes, uncoupling extracellular chemokine gradient sensing from intracellular antigen-processing transcription factor activation and sustaining persistent cross-priming immune response signals. This dual regulation modulates the intensity of chemokine-triggered dendritic cell migratory responses after chemokine gradient exposure, fine-tuning local antigen cross-presentation and T cell priming mediator secretion levels, while sustained abnormal XCR1-mediated signal transmission drives impaired lymphoid immune surveillance and anti-tumor immune defects. XCR1 participates in key physiological and pathological processes including dendritic cell lymphoid trafficking, antigen cross-presentation, cytotoxic T cell priming and chronic immune-suppressive tumor disorders. Dysregulation of XCR1 expression or G protein coupling capacity is closely associated with blunted cross-presenting immune responses and impaired anti-pathogen immune defense, making XCR1 a crucial research target for dendritic cell chemokine signaling, cross-presentation immunity and tumor immunology research.
Fig. 1 Stepwise model of NK cell-derived XCL1 recruiting XCR1⁺ cDC1 to orchestrate tumor antigen cross-presentation and CD8⁺ T cell-mediated tumor elimination.1
The biological functions of XCR1 are focused on chemokine-dependent G protein coupling assembly, cross-priming immune signal propagation and lymphoid immune balance:
Creative Biolabs offers high-purity XCR1 proteins through optimized heterologous expression systems, including full-length XCR1. These products are suitable for dendritic cell chemokine signaling research, receptor-G protein complex interaction detection, and small molecule immune priming modulator screening for tumor immune disorder research. All XCR1 proteins undergo strict quality control, including purity analysis and biological activity validation to ensure biological function.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered XCR1 stable cell lines, including overexpressing and knockdown models in dendritic and lymphoid stromal cell models. These cell lines are optimized for studying XCR1-mediated G protein coupling assembly mechanisms, chemokine-driven cross-presentation signal cascade dynamics, and immune priming modulator sensitivity. Each cell line undergoes stringent validation, including stable expression detection and functional integrity verification.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting XCR1 are developed via advanced antibody engineering technologies. These antibodies are validated for multiple applications, including immunofluorescence for XCR1 dendritic cell membrane localization, Western blot for expression analysis, and co-immunoprecipitation for XCR1-G protein complex research, enabling precise analysis of XCR1 expression, subcellular localization and functional regulation.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for XCR1 research:
XCR1 is a dendritic cell-restricted chemokine GPCR that associates with cytoplasmic G protein trimers upon XCL chemokine stimulation to modulate lymphoid migratory and cross-presentation signal amplitude, balance cytotoxic T cell priming dynamics, and mediate anti-tumor immune activation under chemokine gradient conditions.
XCR1 is the core lineage-specific regulator of type 1 dendritic cell trafficking and antigen cross-presentation immunity, and its dysregulation is associated with blunted cytotoxic T cell priming and chronic immune-suppressive tumor lesions. It is a critical target for dendritic cell chemokine receptor and tumor immunology research.
No, all XCR1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include XCR1 proteins (full-length, extracellular chemokine-binding domain variants), specific recombinant antibodies, and custom stable dendritic cell lines, supporting cross-presentation and tumor immune research.
XCR1 proteins are validated by G protein heterotrimer binding assays and chemokine-driven cross-presentation signal regulation verification to ensure native regulatory function in dendritic cell immune research.
