Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsHaving problems screening your peptides for drug development? We have a ready to order Phage Display TriCo-16 Linear 16-mer Peptide Library to streamline your peptide screening process. Our modern phage display technology with incomparable diversity and our customized randomization method, provides you with the best peptide library to speedily screen and identify high affinity peptides for therapeutic and diagnostic development.
| Library ID | TriCo-16 | Library Format | 16-mer peptide |
| Display Technology | M13 pIII fusion, True phage display system | Randomization | Trimer codon, avoid stop and non-sense codon |
| Vector System | M13KE | Host Strain | E. coli K12, ER2738 |
| Library Capacity | 1.1×1010 | Tags | / |
The TriCo-16 is a high-diversity, ready-to-use library of 16-mer peptides, that provides you with the tools for efficient and fast screening of novel binders to a wide range of biological targets. With high-quality QC results, most of the randomly picked clones from our libraries were found to have dsDNA inserts and none of them had a stop codon, single nucleotide deletion or insertion, non-sense frame-shift mutations or wrong Cys encoding codon were found, as designed.
Using a tried and true phage display system, we make it possible for you to quickly identify specific, high affinity peptide ligands that can bind to, and modulate, nearly any target molecule. With unparalleled sensitivity and specificity, our system is optimized for both basic research and clinical development.
The Trico-16 peptide library, with an ultra-high number of peptide variants, can be easily adapted to different screening conditions, and customized to screen for peptide targets for optimization according to your research focus.
The TriCo-16 library was designed to help you identify peptide candidates that will bind with greater specificity and affinity to your target, reducing off-target effects, and improving the therapeutic potential of your drug candidates.
Integrated with our high-throughput screening platform, the TriCo-16 library allows for rapid and large-scale screening, to quickly identify drug candidates.
We understand that each project has different licensing needs, whether for academic research or industrial application. Here are the available licensing options to suit your requirements:
| License Type | Description |
| Research License (Academic) | Includes one vial of the library (enough for 10 biopanning projects). Limited to academic use; customers cannot amplify the library. No renewal fees unless additional material is needed. |
| Research License (Industry) | Includes the ability to amplify the library. No expiration; customers can contact us for continuous supply. Suitable for pre-IND development. |
| Commercial License | One-time payment to authorize all rights, with limitations on selling, sharing, or providing the library as a product or service to third parties. Perfect for full commercial use. |
With our Phage Display TriCo-16 Peptide Library you get an advanced platform for the discovery of peptides that can bind to a wide range of targets, including proteins, small molecules and even complex cell-based systems.
| Epitope Specific Peptide Discovery | Cell-Targeted Peptide Discovery | Disease-Specific Peptide Discovery |
| Particulate Matter Binding Peptide Screening | Soft Matter Binding Peptide Screening |
To simplify your research process, we offer a seamless, comprehensive workflow:
Submit your antigen (e.g., recombinant protein, peptide, cells, etc.) for screening.
We perform multi-round customized biopanning to identify high-affinity binders.
Receive detailed reports, including peptide sequences, binding data, and clone information.
Our experts are there to support your peptide optimization and validation efforts.
Ready to begin?
| Target Protein Binding Peptide Screening using TriCo-16 and TriCo-20 libraries | ||
| Objective | To rapidly identify novel peptide sequences with high-affinity binding to a specific target protein using our TriCo-16 and TriCo-20 phage display peptide libraries. | |
| Strategy | We conducted a comprehensive four-round screening process using both the TriCo-16 and TriCo-20 phage display peptide libraries. Following screening, preliminary validation and deep sequencing were performed using small-scale phage ELISA to monitor the binding activity and enrichment efficiency. | |
| Key Results |
1. Initial Discovery & Enrichment Through the iterative four-round screening and preliminary phage ELISA validation, we initially identified 3-5 promising target peptide sequences. This initial success demonstrated the effectiveness of our screening protocol in enriching for binders. |
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2. Deep Sequencing for Comprehensive Discovery To maximize the discovery of potential peptide binders and to analyze their binding motifs comprehensively, we performed Next-Generation Sequencing (NGS) on the enriched phage pools. The NGS analysis revealed that the top 10 most abundant sequences accounted for approximately half of the total abundance, indicating a strong enrichment of specific binders. |
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3. Synthesis and Validation of Top Binders The identified top 10 peptide sequences from the NGS analysis were subsequently synthesized for further activity validation. All top 10 synthesized peptides demonstrated strong positive binding to the target protein, confirming their high affinity and specificity. 
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This project successfully identified multiple high-affinity peptide binders for the target protein by combining efficient phage display screening with advanced NGS analysis. Our ability to not only isolate initial candidates but also deeply characterize the enriched library to uncover a diverse set of strong binders, followed by successful synthesis and validation, underscores our comprehensive service capabilities in peptide discovery and development.
In addition to the Phage Display TriCo-16 Peptide Library, we offer a variety of premade peptide libraries for diverse research needs. These libraries are perfect for supporting a range of applications, from target discovery to therapeutic development. We also provide comprehensive screening services to help you identify high-affinity binders from our premade peptide libraries.
| Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| TriCo-16 | pIII-fusion, True Phage Display | 16-mer peptide library | 1.1×1010 | ✔️ |
| TriCo-20 | pIII-fusion, True Phage Display | 20-mer peptide library | 1.3×1010 | ✔️ |
| TriCo-C9 | pIII-fusion, Phagemid Phage Display | Cyclic 9-mer peptide library | 1.1×1010 | ✔️ |
| TriCo-C9L | pIII-fusion, Phagemid Phage Display | Cyclic 9-mer peptide library | 6.8×1010 | Screening-only |
| Protease-10A | pIII-fusion, Phagemid Phage Display | HiAffi tagged 10 mer peptide library | 1.1×1010 | ✔️ |
Need assistance or more information? Reach out to us, and we'll be happy to guide you in selecting the ideal peptide library and screening service for your needs!
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
