Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe HuFabssL-1 Human Semi-Synthetic Fab Antibody Library delivers precision and flexibility for modern antibody discovery. Built upon advanced phagemid phage display technology, this powerful platform blends a wide collection of human Fab genes with a synthetic, high-diversity HCDR3 region - enabling researchers to isolate high-affinity antibodies against a broad spectrum of target types. If you’re seeking next-generation screening performance, HuFabssL-1 is your trusted starting point.
| Species | Human | Library ID | HuFabssL-1 |
| Display Technology | pIII-fusion, Phagemid phage display system | Library Format | Fab format |
| Vector System | PUC119 | Tags | His tag |
| Library Capacity | 1.8×1010 | Library Source | Collections of human Fab V genes from 2000+ naïve donors introduced a synthetic trimer-codon HCDR3 |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
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Human-Origin with Synthetic Precision The HuFabssL-1 library combines naturally occurring human Fab variable regions with a synthetically engineered trimer-codon HCDR3, creating an unparalleled level of combinatorial diversity. This unique design enables highly precise epitope recognition for optimized targeting. |
Broad Target Versatility Whether you're targeting small molecules, membrane proteins, or complex cell-surface receptors, the HuFabssL-1 library is versatile enough to support a wide range of applications. This includes advanced formats such as bispecific and internalizing antibodies, making it an ideal choice for various therapeutic and diagnostic projects. |
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Second-Largest Donor Source with High Screening Success Rates The HuFabssL-1 library stands as our second-largest donor-derived library, providing a robust and diverse repertoire of antibodies. Thanks to its rich diversity and carefully engineered design, the library boasts an impressively high success rate in screening projects, ensuring you achieve your discovery goals with greater efficiency and reliability. |
High-Throughput, Scalable, and Efficient Designed with scalability in mind, the HuFabssL-1 library is both robust and adaptable to projects of varying sizes. It supports both targeted and broad discovery projects, delivering consistently reproducible results without compromising on diversity or affinity. |
Available Screening Service Types
Creative Biolabs provides comprehensive screening services using the HuFabssL-1 library to match your research focus:
| Antibody Types: | |||
| Bispecific Antibodies | Anti-Idiotype Antibodies | Anti-Epitope Antibodies | Cell-Internalizing Antibodies |
| Target Categories: | |||
| Membrane Protein Targets | Cell-based Targets | Enzymes | MHC-Peptide Complexes |
| Disease and Biomarker Targets: | Viral Antigens | Cancer Antigens | Receptor Targets |
| Small Molecule Targets | Toxin Targets | ||
How Our Screening Process Works
Provide information on your target and any special requirements.
Using the HuFabssL-1 library, we perform binder selection through customized biopanning approaches, depending on the characteristics of your target.
Receive detailed report including enrichment of screening, validations of selected clones, and DNA sequences of selected clones.
From consultation to data analysis, our scientific team offers responsive support at every stage.
Note: Screening services only. No enriched libraries provided.
| Case: Soluble Fab Screening Against Cell Surface Antigen | |
| Project Goal | Identify Fab fragments specific to a membrane receptor. |
| In-Solution Screening Strategy | 4 rounds of panning using target membrane proteins and pre-absorption with irrelevant membrane proteins. |
| Key Results |
 Fig 1. Screening progress curve showing enrichment across rounds.  Fig 2. Phage ELISA of random monoclonal clones (part of data; 20+ positive binders).  Fig 3. DNA sequence alignment reveals 5 unique Fab sequences.  Fig 4. Soluble ELISA confirms high specificity and low off-target cross-reactivity. |
| Species | Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| Human | HuScL-6 | pIII-fusion, Phagemid Phage Display | Naïve scFv | 2.1×1011 | Screening-only |
| HuScL-7 | pIII-fusion, Phagemid Phage Display | Naïve scFv | 1.1×1010 | ✔️ | |
| HuScL-3S | pIII-fusion, Phagemid Phage Display | Semi-synthetic scFv | >1.0×1011 | Screening-only | |
| HuFabL-4 | pIII-fusion, Phagemid Phage Display | Naïve Fab | 1.9×1010 | Screening-only | |
| HuFabL-5 | pIII-fusion, Phagemid Phage Display | Naïve Fab | 1.1×1010 | ✔️ | |
| HuFabssL-1 | pIII-fusion, Phagemid Phage Display | Naïve & synthetic Fab | 1.8×1010 | Screening-only | |
| HuscL-YDP-3 | Yeast Display | Naïve scFv | 1.9×108 | ✔️ |
Ready to Get Started?
Contact Creative Biolabs today to discuss your project needs. Let’s unlock the next generation of antibody therapeutics - together.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
