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Guinea Pig Hybridoma Introduction

Guinea pigs are a significant model for immune detection of human infectious diseases, vital for the research of bacterial, viral, parasitic, and other infectious diseases. Guinea pig antibodies developed using hybridomas are crucial tools for studying these diseases and have a role in the diagnosis and treatment of these diseases.

Characteristics of Guinea Pigs

The guinea pig is third only to the mouse and the rat among rodents in the laboratory. Guinea pigs have many special physiological advantages that make them essential in biological experiments. In the aspect of immunology, the serum of guinea pigs, especially the aged females, is rich in complement, which is the most abundant in all experimental animals. In the field of infectious diseases, guinea pigs are sensitive to a variety of pathogens and are often used for pathogen isolation and diagnosis. In the field of drug research, guinea pigs have a long gestation period and a fully developed fetus, and young rats have matured in morphology and function, which makes them suitable for testing the effects of drugs or poisons on later fetal development. In terms of nutrition, guinea pigs cannot synthesize vitamin C in vivo and are very sensitive to its deficiency.

Guinea Pig Hybridoma

Antibody production from hybridomas using guinea pigs is a widely used technique in the research field. About 107 spleen cells could be isolated from the spleen of guinea pigs, which is comparable to the number of rats and about twice that of mice. Thus, more antibodies can be obtained.

Due to their many physiological characteristics, guinea pigs are very suitable for the production of antibodies related to infectious diseases. Guinea pig hybridomas have many advantages, such as a high antibody level, strong affinity, and an extremely high cell fusion rate, which facilitates high-throughput analysis of monoclonal antibody pools and is suitable for a wide range of in vitro and in vivo hybridoma screening and characterization assays.

Creative Biolabs would like to share our experience regarding the field of guinea pig hybridoma. We sincerely hope your research goes well.


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