Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMonoclonal antibody (mAb) has become an important tool for the detection of specific substances in the field of biology and medicine. Hybridoma cell culture in vitro is an important way to prepare mAb. Traditional culture media need to be supplemented with serum, which will cause batch-to-batch differences, instability of the culture system, and risk of contamination. Creative Biolabs has considerable experience in the development and optimization of hybridoma. We have established a complete hybridoma suspension domestication system that can gradually transform the culture method from serum-containing media to serum-free media. Hybridoma can thus be cultured in suspension instead of semi-adherent style.
The most commonly used media formulations for hybridoma culture are Dulbecco's modified Eagle's medium (DMEM) and RPMI-1640, and these basal media are frequently supplemented with fetal bovine serum (FBS). Traditionally, tissue culture media have required serum supplementation to support long-term culture of cells. FBS and other animal products, in general, are plagued by inconsistent product lots, mainly because the source material can be so different based on their age, sex and where they live, what they eat, etc. Some lots of FBS may contain little contamination, and the nutrient or vitamin components may vary in different lots. All these inconsistencies have a significant impact on cells as well as their antibody production, which makes manufacturing difficult. Although it may be solved by screening multiple lots of FBS and buying suitable lot in large quantities, the screening process is time-consuming and purchasing large qualities of FBS at a time is costly. More importantly, FBS contaminates antibodies which reduce the overall purity of the produced mAb.
Serum-free media are highly effective for the culture of parental cells before fusion and even during the selection of hybridomas immediately after fusion. The replacement of the serum-containing medium with serum-free medium provides great ethical and scientific advantages for further antibody purification.
With deep understanding of hybridoma development, Creative Biolabs offers hybridoma suspension domestication service to help clients save valuable hybridoma clones and bring them back to good condition. If you are interested in our services, please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
