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NativeExtract™ Recombinant Full Length Human ABCG2 Protein (Nanodisc, FLAG-tagged) (CAT#: SYF-0426-CW12)

This product is recombinant Human ABCG2 protein in native nanodisc form. The synthetic compound we developed can solubilize the ABCG2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ABCG2
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 72.3 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ABCG2
  • Full Name
  • ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)
  • Introduction
  • The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; CD338; GOUT1; MXR-1; CDw338; CDw388; UAQTL1; EST157481

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