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NativeExtract™ Recombinant Full Length Human GRIA2 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW145)

Name: NativeExtract™ Recombinant Full Length Human GRIA2 Protein (Nanodisc, FLAG- & Strep-tagged)
SKU: SYF-0426-CW145
Rating: 5 (1 reviews)

Datasheet

This product is recombinant Human GRIA2 protein in native nanodisc form. The synthetic compound we developed can solubilize the GRIA2 protein from membrane while retaining the native structure.

Product Specifications

Host Species
Human

Target Protein
GRIA2

Protein Length
Full length

Protein Class
Ion Channel

Molecular Weight
98.8 kDa

Sequence
Accession #P42262

Product Description

Activity
Yes

Application
ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays

Expression Systems
HEK293 expression system

Tag
The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.

Protein Format
Nanodisc

Buffer
20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

Target Protein
GRIA2

Full Name
Glutamate Ionotropic Receptor AMPA Type Subunit 2

Introduction
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Alternative Names
GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2

Gene ID
2891

UniProt ID
P42262

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