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NativeExtract™ Recombinant Full Length Human ACHD Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW69)

This product is recombinant Human ACHD protein in native nanodisc form. The synthetic compound we developed can solubilize the ACHD protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACHD
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 58.9 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ACHD
  • Full Name
  • Cholinergic Receptor Nicotinic Delta Subunit
  • Introduction
  • The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • Cholinergic Receptor Nicotinic Delta Subunit; Acetylcholine Receptor, Nicotinic, Delta (Muscle); Cholinergic Receptor, Nicotinic, Delta (Muscle); Cholinergic Receptor, Nicotinic Delta; ACHRD; Cholinergic Receptor, Nicotinic, Delta Polypeptide; Cholinergic Receptor, Nicotinic, Delta; Acetylcholine Receptor Subunit Delta

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