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NativeExtract™ Recombinant Full Length Human SCNNA Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW89)

This product is recombinant Human SCNNA protein in native nanodisc form. The synthetic compound we developed can solubilize the SCNNA protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SCNNA
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 75.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • SCNNA
  • Full Name
  • Sodium Channel Epithelial 1 Alpha Subunit
  • Introduction
  • Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Alternative Names
  • Sodium Channel Epithelial 1 Alpha Subunit; Sodium Channel, Non Voltage Gated 1 Alpha Subunit; Nonvoltage-Gated Sodium Channel 1 Subunit Alpha; Sodium Channel, Non-Voltage-Gated 1 Alpha; Sodium Channel, Nonvoltage-Gated 1 Alpha; Epithelial Na(+) Channel Subunit Alpha; Alpha-ENaC; Alpha-NaCH; ENaCa; SCNN1

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