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NativeExtract™ Recombinant Full Length Human CAC1H Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW208)

Datasheet
This product is recombinant Human CAC1H protein in native nanodisc form. The synthetic compound we developed can solubilize the CAC1H protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CAC1H
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 259.2 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CAC1H
  • Full Name
  • Calcium Voltage-Gated Channel Subunit Alpha1 H
  • Introduction
  • This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).
  • Alternative Names
  • Calcium Voltage-Gated Channel Subunit Alpha1 H; Calcium Channel, Voltage-Dependent, T Type, Alpha 1H Subunit; Low-Voltage-Activated Calcium Channel Alpha1 3.2 Subunit; Voltage-Gated Calcium Channel Subunit Alpha Cav3.2; Calcium Channel, Voltage-Dependent, T Type, Alpha 1Hb Subunit; Voltage Dependent T-Type Calcium Channel Alpha-1H Subunit; Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H; Low-Voltage-Activated Calcium Channel Alpha13.2 Subunit

Case Studies

Customer reviews and Q&As    

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