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NativeExtract™ Recombinant Full Length Human ACHG Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW67)

Datasheet
This product is recombinant Human ACHG protein in native nanodisc form. The synthetic compound we developed can solubilize the ACHG protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACHG
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 57.9 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ACHG
  • Full Name
  • Cholinergic Receptor Nicotinic Gamma Subunit
  • Introduction
  • The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
  • Alternative Names
  • Cholinergic Receptor Nicotinic Gamma Subunit; Acetylcholine Receptor, Nicotinic, Gamma (Muscle); Cholinergic Receptor, Nicotinic, Gamma (Muscle); Cholinergic Receptor, Nicotinic Gamma; ACHRG; Cholinergic Receptor, Nicotinic, Gamma Polypeptide; Acetylcholine Receptor, Muscle, Gamma Subunit; Cholinergic Receptor, Nicotinic, Gamma; Acetylcholine Receptor Subunit Gamma

Case Studies

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