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NativeExtract™ Recombinant Full Length Human ASIC2 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW130)

This product is recombinant Human ASIC2 protein in native nanodisc form. The synthetic compound we developed can solubilize the ASIC2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ASIC2
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 57.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ASIC2
  • Full Name
  • Acid Sensing Ion Channel Subunit 2
  • Introduction
  • This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.
  • Alternative Names
  • Acid Sensing Ion Channel Subunit 2; Amiloride-Sensitive Cation Channel 1, Neuronal; Mammalian Degenerin Homolog; Brain Sodium Channel 1; ACCN1; BNaC1; ACCN; BNC1; MDEG; Neuronal Amiloride-Sensitive Cation Channel 1
  • Gene ID
  • 40

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