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NativeExtract™ Recombinant Full Length Human TRPV1 Protein (Nanodisc, MBP-, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW290)

This product is recombinant Human TRPV1 protein in native nanodisc form. The synthetic compound we developed can solubilize the TRPV1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TRPV1
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 135.0 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus and MBP Tag at N terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • TRPV1
  • Full Name
  • Transient Receptor Potential Cation Channel Subfamily V Member 1
  • Introduction
  • Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
  • Alternative Names
  • Transient Receptor Potential Cation Channel Subfamily V Member 1; Vanilloid Receptor Subtype 1; Osm-9-Like TRP Channel 1; Capsaicin Receptor; OTRPC1; VR1

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