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NativeExtract™ Recombinant Full Length Human CA2D2 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW147)

Datasheet
This product is recombinant Human CA2D2 protein in native nanodisc form. The synthetic compound we developed can solubilize the CA2D2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CA2D2
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 129.8 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CA2D2
  • Full Name
  • Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2Delta 2
  • Introduction
  • Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2; Calcium Channel, Voltage-Dependent, Alpha 2/Delta Subunit 2; Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2; Gene 26; Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2; Alpha 2 Delta Calcium Channel Subunit; KIAA0558; CACNA2D

Case Studies

Customer reviews and Q&As    

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