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NativeExtract™ Recombinant Full Length Human ASIC4 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW272)

This product is recombinant Human ASIC4 protein in native nanodisc form. The synthetic compound we developed can solubilize the ASIC4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ASIC4
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 70.1 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ASIC4
  • Full Name
  • Acid Sensing Ion Channel Subunit Family Member 4
  • Introduction
  • This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC.
  • Alternative Names
  • Acid Sensing Ion Channel Subunit Family Member 4; Amiloride-Sensitive Cation Channel 4, Pituitary; Acid-Sensing (Proton-Gated) Ion Channel Family Member 4; Acid Sensing Ion Channel Family Member 4; ACCN4; Amiloride-Sensitive Cation Channel Family Member 4, Pituitary

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