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NativeExtract™ Recombinant Full Length Human CAC1A Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW197)

Datasheet
This product is recombinant Human CAC1A protein in native nanodisc form. The synthetic compound we developed can solubilize the CAC1A protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CAC1A
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 282.6 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CAC1A
  • Full Name
  • Calcium Voltage-Gated Channel Subunit Alpha1 A
  • Introduction
  • Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6.
  • Alternative Names
  • Calcium Voltage-Gated Channel Subunit Alpha1 A; Calcium Channel, Voltage-Dependent, P/Q Type, Alpha 1A Subunit; Voltage-Gated Calcium Channel Subunit Alpha Cav2.1; Brain Calcium Channel I; CACNL1A4; BI; Fetal Brain Ca2+ Voltage-Gated Channel Alpha1A Pore-Forming Subunit; Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1A; Calcium Channel, L Type, Alpha-1 Polypeptide Isoform 4; Calcium Channel, L Type, Alpha-1 Polypeptide; Brain Calcium Channel 1; CAV2.1

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