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NativeExtract™ Recombinant Full Length Human CLDN18.1 Protein (Petitide Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW311)

This product is recombinant full length Human CLDN18.1 protein in peptide nanodisc form. The synthetic peptide scaffold we developed can extract and stabilize the CLDN18.1 protein while preserving its native conformation.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLDN18.1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 27.9 kDa
  • Sequence
  • Our product features full-length membrane proteins with complete, native sequences, ensuring optimal structural integrity and functional activity for your research needs.

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLDN18.1
  • Full Name
  • claudin 18
  • Introduction
  • CLDN18.1 is a member of the claudin family, a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails. It is specifically expressed in the lung, where it regulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress cell proliferation by inhibiting the IGF-1R/AKT signaling axis. CLDN18.1 plays a crucial role in lung biology and is associated with both lung diseases and cancer treatment potential.
  • Alternative Names
  • SFTA5; SFTPJ

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