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NativeExtract™ Recombinant Full Length Human CLDN6 Protein (Petitide Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW309)

This product is recombinant full length Human CLDN6 protein in peptide nanodisc form. The synthetic peptide scaffold we developed can extract and stabilize the CLDN6 protein while preserving its native conformation.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLDN6
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 23.3 kDa
  • Sequence
  • Our product features full-length membrane proteins with complete, native sequences, ensuring optimal structural integrity and functional activity for your research needs.

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLDN6
  • Full Name
  • claudin 6
  • Introduction
  • Claudin-6 (CLDN6) is a member of the claudin family and a transmembrane protein located in tight junctions, characterized by two extracellular loops and intracellular N and C-terminal tails. CLDN6 regulates the ion- and charge-specific permeability of the paracellular pathway in various epithelial tissues. In the kidney, it controls the paracellular flux of cations by forming heterotypic strands with other claudins, and it plays a crucial role in maintaining the lung epithelial barrier function. The CLDN6 gene is located near another claudin family member, CLDN9, on chromosome 16. In certain CLDN6-positive cancers, including ovarian, endometrial, and testicular malignancies, silencing CLDN6 has been shown to suppress cell proliferation and invasiveness.

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