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NativeExtract™ Recombinant Full Length Human ACHB3 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW265)

Datasheet
This product is recombinant Human ACHB3 protein in native nanodisc form. The synthetic compound we developed can solubilize the ACHB3 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ACHB3
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 52.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ACHB3
  • Full Name
  • Cholinergic Receptor Nicotinic Beta 3 Subunit
  • Introduction
  • The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 ). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]
  • Alternative Names
  • Cholinergic Receptor Nicotinic Beta 3 Subunit; Acetylcholine Receptor, Nicotinic, Beta 3 (Neuronal); Cholinergic Receptor, Nicotinic, Beta Polypeptide 3; Cholinergic Receptor, Nicotinic, Beta 3 (Neuronal); Cholinergic Receptor, Nicotinic Beta 3

Case Studies

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