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NativeExtract™ Recombinant Full Length Human SCN1B Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW154)

This product is recombinant Human SCN1B protein in native nanodisc form. The synthetic compound we developed can solubilize the SCN1B protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SCN1B
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 24.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • SCN1B
  • Full Name
  • Sodium Voltage-Gated Channel Beta Subunit 1
  • Introduction
  • Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • Sodium Voltage-Gated Channel Beta Subunit 1; Sodium Channel, Voltage Gated, Type I Beta Subunit; Sodium Channel, Voltage-Gated, Type I, Beta; Sodium Channel, Voltage-Gated, Type I, Beta Polypeptide; Sodium Channel, Voltage-Gated, Type I, Beta Subunit; Sodium Channel Subunit Beta-1

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