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NativeExtract™ Recombinant Full Length Human TRPM6 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW185)

This product is recombinant Human TRPM6 protein in native nanodisc form. The synthetic compound we developed can solubilize the TRPM6 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TRPM6
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 231.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • TRPM6
  • Full Name
  • Transient Receptor Potential Cation Channel Subfamily M Member 6
  • Introduction
  • This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Alternative Names
  • Transient Receptor Potential Cation Channel Subfamily M Member 6; Melastatin-Related TRP Cation Channel 6; Channel Kinase 2; EC 2.7.11.1; CHAK2; Transient Receptor Potential Cation Channel, Subfamily M, Member 6

Case Studies

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