Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs has long time been the world-leading provider of VLPs. With our vast experience and advanced platforms, we are pleased to provide a complete line of VLP production services based on our advanced expression system to help customers reach their project goals.
Structurally, SARS-CoV-2 has four main structural proteins including spike (S) glycoprotein, small envelope (E) glycoprotein, membrane (M) glycoprotein, and nucleocapsid (N) protein, and also several accessory proteins. Non-infectious VLPs displaying essential viral proteins can be used to study the structural properties of the SARS-CoV-2 virions and due to their maximum immunogenicity are also vaccine candidates. VLPs are released from cells with similar mechanisms as fully infectious virions and resemble the shape and composition of fully infectious virions. Currently, Creative Biolabs has successfully created VLPs composed of S, M, E or S, M, N, E in mammalian cells and insect cell expression systems.
Fig.1 Structure of SARS-CoV-2.1
The simplest system for SARS-CoV-2 VLPs production might include both M and E5, M, E and S7, or M and E with N, which is critical for VLP production. Based on years of experience producing VLPs, Creative Biolabs optimizes VLP manufacturing from DNA plasmid ratios of M, N, E, or S. We also enhanced the manufacture of fluorescent VLPs containing tagged structural SARS-CoV-2 proteins, creating a useful tool for imaging and studying SARS-CoV-2 assembly and entrance. We characterize these VLPs using sophisticated microscopy methods. These approaches allow us to measure the size, number, and shape of VLPs, which we can then compare to wild-type SARS-CoV-2 particles.
Fig.2 Analysis of RNA-transfected Sf21 cells. A) non-Fluorescence, B) Fluorescence.
Creative Biolabs now offers high-quality VLP product services for customers in the world. Our seasoned scientific staff will work closely with you to keep you apprised of project progress while taking all your goals into account. Now, we are proud to provide SARS-CoV-2 VLP products, containing S/M/E or S/M/E/N to advance SARS-CoV-2 researches. What's more, we provide VLP products labeled with GFP if customers want to put the dye marker for VLPs. Please feel free to search our catalog for any peptide products. If you cannot find the suitable products you desire, please do not hesitate to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
